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TRR259_Logo_Rund_TransparentMulti-targeted 1H/19F MRI unmasks specific danger patterns for emerging cardiovascular disorders

Flögel U, Temme S, Jacoby C, Oerther T, Keul P, Flocke V, Wang X, Bönner F, Nienhaus F, Peter K, Schrader J, Grandoch M, Kelm M, Levkau B.

Nat Commun. 2021 Oct 6;12(1):5847. doi: 10.1038/s41467-021-26146-6. PMID: 34615876; PMCID: PMC8494909.


TRR259_Logo_Rund_TransparentESC/EACTS-Leitlinien 2021 zum Management von Herzklappenerkrankungen

Nettersheim FS, Baldus S

Herz 2021. Published online October 5, 2021:1-12. doi:10.1007/S00059-021-05068-5

TRR259_Logo_Rund_TransparentDisrupted PI3K subunit p110α signaling protects against pulmonary hypertension and reverses established disease in rodents

Berghausen EM, Janssen W, Vantler M, Gnatzy-Feik LL, Krause M, Behringer A, Joseph C, Zierden M, Freyhaus HT, Klinke A, Baldus S, Alcazar MA, Savai R, Pullamsetti SS, Wong DW, Boor P, Zhao JJ, Schermuly RT, Rosenkranz S.

J Clin Invest. 2021 Oct 1;131(19):e136939. doi: 10.1172/JCI136939. PMID: 34596056; PMCID: PMC8483754.


TRR259_Logo_Rund_TransparentPeri-Adventitial delivery of smooth muscle cells in porous collagen scaffolds for treatment of experimental abdominal aortic aneurysm

Mulorz J, Shayan M, Hu C, Alcazar C, Chan AHP, Briggs M, Wen Y, Walvekar AP, Ramasubramanian AK, Spin JM, Chen B, Tsao PS, Huang NF. .

Biomater Sci. 2021 Sep 15. doi: 10.1039/d1bm00685a. Epub ahead of print. PMID: 34522940


TRR259_Logo_Rund_TransparentInhibition of Rac1 GTPase Decreases Vascular Oxidative Stress, Improves Endothelial Function, and Attenuates Atherosclerosis Development in Mice

Zimmer S, Goody PR, Oelze M, Ghanem A, Mueller CF, Laufs U, Daiber A, Jansen F, Nickenig G, Wassmann S.

Front Cardiovasc Med. 2021 Aug 6;8:680775. doi: 10.3389/fcvm.2021.680775. PMID: 34422919; PMCID: PMC8377253.


TRR259_Logo_Rund_TransparentExtracellular Vesicle Separation Techniques Impact Results from Human Blood Samples: Considerations for Diagnostic Applications

Tzaridis T, Bachurski D, Liu S, Surmann K, Babatz F, Gesell Salazar M, Völker U, Hallek M, Herrlinger U, Vorberg I, Coch C, Reiners KS, Hartmann G.

Int J Mol Sci. 2021 Aug 26;22(17):9211. doi: 10.3390/ijms22179211. PMID: 34502122; PMCID: PMC8431127.


TRR259_Logo_Rund_TransparentGimme' the Loop: Modifications to the Squid-Capture Technique for Laser-Fenestrated Thoracic Endografting

Mulorz J, Knapsis A, Ertas N, Schelzig H, Wagenhäuser MU. 

J Endovasc Ther. 2021 Aug;28(4):524-529. doi: 10.1177/15266028211007475. Epub 2021 Apr 15. PMID: 33855878; PMCID: PMC8276338.


TRR259_Logo_Rund_TransparentNitro-Oleic Acid (NO 2-OA) Improves Systolic Function in Dilated Cardiomyopathy by Attenuating Myocardial Fibrosis

Braumann S, Schumacher W, Im NG, Nettersheim FS, Mehrkens D, Bokredenghel S, Hof A, Nies RJ, Adler C, Winkels H, Knöll R, Freeman BA, Rudolph V, Klinke A, Adam M, Baldus S, Mollenhauer M, Geißen S. 

Int J Mol Sci. 2021 Aug 22;22(16):9052. doi: 10.3390/ijms22169052. PMID: 34445757; PMCID: PMC8396484


TRR259_Logo_Rund_TransparentOutflow Through Aortic Side Branches Drives False Lumen Patency in Type B Aortic Dissection

Gerlinde Logghe, Bram Trachet, Patrick Segers, Julie De Backer, Joscha Mulorz, Philip Düppers, Frank Vermassen, Hubert Schelzig, Isabelle van Herzeele, Markus Udo Wagenhäuser.

Front Cardiovasc Med. 2021 Aug 13;0:822. doi:10.3389/FCVM.2021.710603


TRR259_Logo_Rund_TransparentNitro-oleic acid (NO2-OA) reduces thoracic aortic aneurysm progression in a mouse model of Marfan syndrome

Nettersheim FS, Lemties J, Braumann S, Geißen S, Bokredenghel S, Nies R, Hof A, Winkels H, Freeman BA, Klinke A, Rudolph V, Baldus S, Mehrkens D, Mollenhauer M, Adam M.

Cardiovasc Res. 2021 Jul 29:cvab256. doi: 10.1093/cvr/cvab256. Epub ahead of print. PMID: 34324651.


TRR259_Logo_Rund_TransparentControlling BMP growth factor bioavailability: The extracellular matrix as multi skilled platform

Zimmermann LA, Correns A, Furlan AG, Spanou CES, Sengle G.

Cell Signal. 2021 Jul 2;85:110071. doi: 10.1016/j.cellsig.2021.110071. Epub ahead of print. PMID: 34217834.


TRR259_Logo_Rund_TransparentHMGB1 coordinates SASP-related chromatin folding and RNA homeostasis on the path to senescence 

Sofiadis K, Josipovic N, Nikolic M, Kargapolova Y, Übelmesser N, Varamogianni-Mamatsi V, Zirkel A, Papadionysiou I, Loughran G, Keane J, Michel A, Gusmao EG, Becker C, Altmüller J, Georgomanolis T, Mizi A, Papantonis A.

Mol Syst Biol. 2021 Jun;17(6):e9760. doi: 10.15252/msb.20209760. PMID: 34166567; PMCID: PMC8224457.


TRR259_Logo_Rund_TransparentDapagliflozin reduces thrombin generation and platelet activation: implications for cardiovascular risk reduction in type 2 diabetes mellitus

Kohlmorgen C, Gerfer S, Feldmann K, Twarock S, Hartwig S, Lehr S, Klier M, Krüger I, Helten C, Keul P, Kahl S, Polzin A, Elvers M, Flögel U, Kelm M, Levkau B, Roden M, Fischer JW, Grandoch M. 

Diabetologia. 2021 Aug;64(8):1834-1849. doi: 10.1007/s00125-021-05498-0. Epub 2021 Jun 16. PMID: 34131781; PMCID: PMC8245397.


Small Blebs, Big Potential — Can Extracellular Vesicles Cure Cardiovascular Disease?

Zietzer, Andreas, Georg Nickenig, and Felix Jansen

European Heart Journal, 2021 <https://doi.org/10.1093/eurheartj/ehab334>


TRR259_Logo_Rund_TransparentCell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular disease.

Lacy, Michael, Christina Bürger, Annelie Shami, Maiwand Ahmadsei, Holger Winkels, Katrin Nitz, and others

Nat Commun 12, 3754 (2021). <https://doi.org/10.1038/s41467-021-23909-z>


TRR259_Logo_Rund_TransparentBi-Allelic Premature Truncating Variants in LTBP1 Cause Cutis Laxa Syndrome

Lore Pottie, Christin S. Adamo, Aude Beyens, Steffen Lütke, Piyanoot Tapaneeyaphan, Adelbert De Clercq, Phil L. Salmon, Riet De Rycke, Alper Gezdirici, Elif Yilmaz Gulec, Naz Khan, Jill E. Urquhart, William G. Newman, Kay Metcalfe, Stephanie Efthymiou, Reza Maroofian, Najwa Anwar, Shazia Maqbool, Fatima Rahman, Ikhlass Altweijri, Monerah Alsaleh, Sawsan Mohamed Abdullah, Mohammad Al-Owain, Mais Hashem, Henry Houlden, Fowzan S. Alkuraya, Patrick Sips, Gerhard Sengle, Bert Callewaert

The American Journal of Human Genetics, June 3, 2021, 1–20 <https://doi.org/10.1016/j.ajhg.2021.04.016>


TRR259_Logo_Rund_TransparentCoronary Artery Disease Increases the Long Noncoding RNA PUNISHER in Small Extracellular Vesicles and Regulates Endothelial Cell Function via Vesicular Shuttling

Hosen, Mohammed Rabiul, Qian Li, Yangyang Liu, Andreas Zietzer, Katharina Maus, Philip Goody, Shizuka Uchida, Eicke Latz, Nikos Werner, Georg Nickenig, Felix Jansen

Molecular Therapy - Nucleic Acids, 2021 <https://doi.org/10.1016/j.omtn.2021.05.023>


TRR259_Logo_Rund_TransparentLarge Extracellular Vesicles in the Left Atrial Appendage in Patients with Atrial Fibrillation—the Missing Link?

Andreas Zietzer, Baravan Al-Kassou, Paul Jamme, Eva Steffen, Marko Bulic, Mohammed Rabiul Hosen, Philip Roger Goody, Vedat Tiyerili, Sebastian Zimmer, Jan Wilko Schrickel, Alexander Sedaghat, Nikos Werner, Georg Nickenig & Felix Jansen

Clin Res Cardiol, 2021 Jun 1. https://doi.org/10.1007/s00392-021-01873-4



TRR259_Logo_Rund_TransparentOverarching control of autophagy and DNA damage response by CHD6 revealed by modeling a rare human pathology.

Kargapolova Y, Rehimi R, Kayserili H, Brühl J, Sofiadis K, Zirkel A, Palikyras S, Mizi A, Li Y, Yigit G, Hoischen A, Frank S, Russ N, Trautwein J, van Bon B, Gilissen C, Laugsch M, Gusmao EG, Josipovic N, Altmüller J, Nürnberg P, Längst G, Kaiser FJ, Watrin E, Brunner H, Rada-Iglesias A, Kurian L, Wollnik B, Bouazoune K, Papantonis A.

Nat Commun. 2021 May 21;12(1):3014. doi: 10.1038/s41467-021-23327-1. PMID: 34021162; PMCID: PMC8140133.


TRR259_Logo_Rund_TransparentRegulation and function of CX3CR1 and its ligand CX3CL1 in kidney disease

Vietinghoff S, Kurts C.

Cell Tissue Res. 2021 May 19. doi: 10.1007/s00441-021-03473-0.


TRR259_Logo_Rund_TransparentThe Enzymatic and Non-Enzymatic Function of Myeloperoxidase (MPO) in Inflammatory Communication

Kargapolova, Yulia, Simon Geißen, Ruiyuan Zheng, Stephan Baldus, Holger Winkels, Matti Adam

Antioxidants, 2021 Apr 5;10(4):562. https://doi.org/10.3390/antiox10040562


TRR259_Logo_Rund_TransparentIncidence, Risk Factors and Impact on Long-Term Outcome of Postoperative Delirium After Transcatheter Aortic Valve Replacement

Mauri, Victor, Kevin Reuter, Maria I Körber, Hendrik Wienemann, Samuel Lee, Kaveh Eghbalzadeh, Elmar Kuhn, Baldus Stephan, Kelm Malte, Nickenig Georg, Veulemans Verena, Jansen Felix, Adam Matti, Rudolph Tanja K

Frontiers in Cardiovascular Medicine, 2021 Mar 26,8, 229

https://doi.org/10.3389/fcvm.2021.645724


TRR259_Logo_Rund_Transparent A new MMP-mediated prodomain cleavage mechanism to activate bone morphogenetic proteins from the extracellular matrix

Furlan AG, Spanou CES, Godwin ARF, Wohl AP, Zimmermann LA, Imhof T, Koch M, Baldock C, Sengle G.

FASEB J. 2021 Mar;35(3):e21353. doi: 10.1096/fj.202001264R. PMID: 33629769


TRR259_Logo_Rund_TransparentSmartphone-guided secondary prevention for patients with coronary artery disease

Eckardt I, Buschhaus C, Nickenig G, Jansen F.

J Rehabil Assist Technol Eng. 2021 Mar 16;8:2055668321996572. doi: 10.1177/2055668321996572. PMID: 33796334; PMCID: PMC7970225.


TRR259_Logo_Rund_Transparent3D-speckle-tracking echocardiography correlates with CMR diagnosis of acute myocarditis

Philip Goody, Sebastian Zimmer, Angela Zimmer, Jens Kreuz, Marc Ulrich Becher, Alexander Isaak, Georg Nickenig, Christoph Hammerstingl, Vedat Tiyerili

Authorea. February 17, 2021


 

TRR259_Logo_Rund_TransparentPhenotyping placental oxygenation in Lgals1 deficient mice using 19F MRI

Boehm-Sturm P, Mueller S, Freitag N, Borowski S, Foddis M, Koch SP, Temme S, Flögel U, Blois SM.  Sci Rep. 2021 Jan 22;11(1):2126. doi: 10.1038/s41598-020-80408-9. PMID: 33483548; PMCID: PMC7822814.


TRR259_Logo_Rund_TransparentTransparentVancomycin and Daptomycin Modulate the Innate Immune Response in a Murine Model of LPS-Induced Sepsis

Muenster, Stefan, Valentina Zschernack, Birte Dierig, Stilla Frede, Georg Baumgarten, Mark Coburn, Christian Putensen and Christina Weisheit

International Journal of Immunopathology and Pharmacology, 35 (Jan. 2021),

doi:10.1177/20587384211031373


TRR259_Logo_Rund_Transparent Helix-Loop-Helix Factor Id3 (Inhibitor of Differentiation 3): A Novel Regulator of Hyaluronan-Mediated Adipose Tissue Inflammation

 Misiou, Angelina, James C. Garmey, Jack M. Hensien, Daniel B. Harmon, Victoria Osinsk, Chantel McSkimming, Melissa A. Marshall, Jens W. Fischer, Maria Grandoch, Coleen A. McNamara

Arteriosclerosis, Thrombosis, and Vascular Biology, 2020 Dec 31, 41, 796–807; https://doi.org/10.1161/atvbaha.120.315588


TRR259_Logo_Rund_TransparentCX3CR1 Is a Prerequisite for the Development of Cardiac Hypertrophy and Left Ventricular Dysfunction in Mice upon Transverse Aortic Constriction

Weisheit, Christina Katharina, Jan Lukas Kleiner, Maria Belen Rodrigo, Sven Thomas Niepmann, Sebastian Zimmer, Georg Daniel Duerr, Mark Coburn, Christian Kurts, Stilla Frede, and Lars Eichhorn. PLoS One. 2021 Jan 7; 16(1):e0243788. doi: 10.1371/journal.pone.0243788


TRR259_Logo_Rund_TransparentVascular pathologies in chronic kidney disease: pathophysiological mechanisms and novel therapeutic approaches

Philip Düsing, Andreas Zietzer, Philip Roger Goody, Mohammed Rabiul Hosen, Christian Kurts, Georg Nickenig, Felix Jansen. J Mol Med, 2021 Jan 22. https://doi.org/10.1007/s00109-021-02037-7


TRR259_Logo_Rund_TransparentQuantification of Lipoprotein Uptake in Vivo Using Magnetic Particle Imaging and Spectroscopy

Hildebrand, Staffan, Norbert Löwa, Hendrik Paysen, Raluca M. Fratila, Laia Reverte-Salisa, Thithawat Trakoolwilaiwan, Zheming Niu, Georgios Kasparis, Stephanie Franziska Preuss, Olaf Kosch, Jesus M. de la Fuente, Nguyen Thi Kim Thanh, Frank Wiekhorst, and Alexander Pfeifer. 2020 Dec 11.  ACS Nano. doi: 10.1021/acsnano.0c03229.

TRR259_Logo_Rund_TransparentVaccination in Atherosclerosis 

Felix Sebastian Nettersheim, Lauren De Vore and Holger Winkels

Cells 2020,Nov 30, 9, 2560, https://doi.org/10.3390/cells9122560


TRR259_Logo_Rund_TransparentMicroRNA-mediated vascular intercellular communication is altered in chronic kidney disease

Andreas Zietzer; Eva Steffen; Sven Niepmann; Philip Düsing; Mohammed Rabiul Hosen; Weiyi Liu; Paul Jamme; Baravan Al-Kassou; Philipp Roger Goody; Sebastian Zimmer; Katrin S Reiners; Alexander Pfeifer; Michael Böhm; Nikos Werner; Georg Nickenig; Felix Jansen,

Cardiovascular Research cvaa322, 2020 Nov. 02, https://doi.org/10.1093/cvr/cvaa322


TRR259_Logo_Rund_TransparentReelin Amplifies Glycoprotein VI Activation and AlphaIIb Beta3 Integrin Outside-In Signaling via PLC Gamma 2 and Rho GTPases

Krueger, Irena, Lothar Gremer, Lena Mangels, Meike Klier, Kerstin Jurk, Dieter Willbold, Hans H. Bock, and Margitta Elvers 

Arteriosclerosis, Thrombosis, and Vascular Biology, 2020 Oct, 40(10):2391–2403. doi: 10.1161/ATVBAHA.120.314902


TRR259_Logo_Rund_TransparentIntegrative Multi-Omics Analysis in Calcific Aortic Valve Disease Reveals a Link to the Formation of Amyloid-Like Deposits

Marina A. Heuschkel, Nikolaos T. Skenteris, Joshua D. Hutcheson, Dewy D. van der Valk, Juliane Bremer, Philip Goody, Jesper Hjortnaes, Felix Jansen, Carlijn V.C. Bouten, Antoon van den Bogaerdt, Ljubica Matic,
Nikolaus Marx and Claudia Goettsch

Cells 2020 Sep 24, 9(10), 2164; https://doi.org/10.3390/cells9102164
 


TRR259_Logo_Rund_TransparentPulmonary hypertension associated with left-sided heart failure

Adler J, Gerhardt F, Wissmüller M, Adler C, Baldus S, Rosenkranz S. Pulmonary hypertension associated with left-sided heart failure. Curr Opin Cardiol. 2020 Sep 21. doi: 10.1097/HCO.0000000000000791. Epub ahead of print. PMID: 32969856


TRR259_Logo_Rund_TransparentNitro-fatty acids suppress ischemic ventricular arrhythmias by preserving calcium homeostasis

Mollenhauer M, Mehrkens D, Klinke A, Lange M, Remane L, Friedrichs K, Braumann S, Geißen S, Simsekyilmaz S, Nettersheim FS, Lee S, Peinkofer G, Geisler AC, Geis B, Schwoerer AP, Carrier L, Freeman BA, Dewenter M, Luo X, El-Armouche A, Wagner M, Adam M, Baldus S, Rudolph V. 

Sci Rep. 2020 Sep 18;10(1):15319. doi: 10.1038/s41598-020-71870-6. PMID: 32948795; PMCID: PMC7501300.


TRR259_Logo_Rund_Transparent  Hyperlipidemia does not affect development of elastase-induced abdominal aortic aneurysm in mice

Joscha Mulorz, Joshua Michael Spin, Hans Christian Beck, My Linh Tha Thi, Markus Udo Wagenhäuser, Lars Melholt Rasmussen, Jes Sanddal Lindholt, Philip Shih Chung Tsao, Lasse Bach Steffensen

Atherosclerosis, 2020 Aug 29, Volume 311, 73 – 83, https://doi.org/10.1016/j.atherosclerosis.2020.08.012


TRR259_Logo_Rund_TransparentNitro-fatty acids suppress ischemic ventricular arrhythmias by preserving calcium homeostasis

Mollenhauer M, Mehrkens D, Klinke A, Lange M, Remane L, Friedrichs K, Braumann S, Geißen S, Simsekyilmaz S, Nettersheim FS, Lee S, Peinkofer G, Geisler AC, Geis B, Schwoerer AP, Carrier L, Freeman BA, Dewenter M, Luo X, El-Armouche A, Wagner M, Adam M, Baldus S, Rudolph V. Nitro-fatty acids suppress ischemic ventricular arrhythmias by preserving calcium homeostasis. Sci Rep. 2020 Sep 18;10(1):15319. doi: 10.1038/s41598-020-71870-6. PMID: 32948795.


TRR259_Logo_Rund_TransparentRisk modeling in transcatheter aortic valve replacement remains unsolved: an external validation study in 2946 German patients.

Wolff G, Shamekhi J, Al-Kassou B, Tabata N, Parco C, Klein K, Maier O, Sedaghat A, Polzin A, Sugiura A, Jung C, Grube E, Westenfeld R, Icks A, Zeus T, Sinning JM, Baldus S, Nickenig G, Kelm M, Veulemans V. 

Clin Res Cardiol. 2020 Aug 26. doi: 10.1007/s00392-020-01731-9. Epub ahead of print. PMID: 32851491.


TRR259_Logo_Rund_TransparentMeta-Analysis of Leukocyte Diversity in Atherosclerotic Mouse Aortas

Zernecke, Alma, Holger Winkels, Clément Cochain, Jesse W. Williams, Dennis Wolf, Oliver Soehnlein, Clint S. Robbins, Claudia Monaco, Inhye Park, Coleen A. McNamara, Christoph J. Binder, Myron I. Cybulsky, Corey A. Scipione, Catherine C. Hedrick, Elena V. Galkina, Tin Kyaw, Yanal Ghosheh, Huy Q. Dinh, and Klaus Ley

Circulation Research, 2020 Jul 16, 127(3):402–26. doi: 10.1161/CIRCRESAHA.120.316903


The RNA-binding protein hnRNPU regulates the sorting of microRNA-30c-5p into large extracellular vesicles

Andreas Zietzer, Mohammed Rabiul Hosen, Han Wang, Philip Roger Goody, Marc Sylvester, Eicke Latz, Georg Nickenig, Nikos Werner & Felix Jansen

 

Journal of Extracellular Vesicles 2020 Jul 02, 9:1, 1786967, DOI: 10.1080/20013078.2020.1786967


Adenosine/A2B Receptor Signaling Ameliorates the Effects of Aging and Counteracts Obesity

Thorsten Gnad, Gemma Navarro, Minna Lahesmaa, Laia Reverte-Salisa, Francesca Copperi, Arnau Cordomi, Jennifer Naumann, Aileen Hochhäuser, Saskia Haufs-Brusberg, Daniela Wenzel, Frank Suhr, Naja Zenius Jespersen, Camilla Scheele, Volodymyr Tsvilovskyy, Christian Brinkmann, Joern Rittweger, Christian Dani, Mathias Kranz, Winnie Deuther-Conrad, Holger K. Eltzschig, Tarja Niemi, Markku Taittonen, Peter Brust, Pirjo Nuutila, Leonardo Pardo, Bernd K. Fleischmann, Matthias Blüher, Rafael Franco, Wilhelm Bloch, Kirsi A. Virtanen, Alexander Pfeifer

Cell Metabolism, 2020 Junehttps://doi.org/10.1016/j.cmet.2020.06.006

TRR259_Logo_Rund_TransparentSustained Immunoparalysis in Endotoxin-Tolerized Monocytic Cells

Christina K. Weisheit, Alexandra Klüners, Lennart Wild, Alexandra Casalter, Stefanie Heilmann-Heimbach, Sugirthan Sivalingam, Jan L. Kleiner, Stefan F. Ehrentraut, Andreas Hoeft, Stilla Frede, and Heidi Ehrentraut

Mediators of Inflammation, 2020 Jun 13, https://doi.org/10.1155/2020/8294342


 

TRR259_Logo_Rund_TransparentMicroRNAs As Master Regulators of Atherosclerosis: From Pathogenesis to Novel Therapeutic Options

Mohammed Rabiul Hosen, Philip Roger Goody, Andreas Zietzer, Georg Nickenig, and Felix Jansen

Antioxidants & Redox Signaling 2020 Junehttps://doi.org/10.1089/ars.2020.8107


TRR259_Logo_Rund_TransparentHot spot 19F magnetic resonance imaging of inflammation

Pascal Bouvain, Sebastian Temme, Ulrich Flögel

Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2020 [published online ahead of print, 2020 May 7].e1639.doi:10.1002/wnan.1639


TRR259_Logo_Rund_Transparent Basic Biology of Extracellular Matrix in the Cardiovascular System, Part 1/4: JACC Focus Seminar

del Monte-Nieto, Gonzalo, Jens W. Fischer, Daniel J. Gorski, Richard P. Harvey, and Jason C. Kovacic

 

Journal of the American College of Cardiology, 2020 May 5, 75(17):2169–88.

 

doi: https://doi.org/10.1016/j.jacc.2020.03.024.


Thymic stromal lymphopoietin is a key cytokine for the immunomodulation of atherogenesis with Freund's adjuvant

Martin Steinmetz, Ludivine Laurans, Sarah Nordsiek, Lena Weiß, Bieke van der Veken, Padmapriya Ponnuswamy, Bruno Esposito, Marie Vandestienne, Andreas Giraud, Cristina Göbbel, Eva Steffen, Tobias Radecke, Stephane Potteaux, Georg Nickenig, Tienush Rassaf, Alain Tedgui, Ziad Mallat

Journal of Cellular and Molecular Medicine 2020 May;24(10) 5731-5739; DOI: 10.1111/jcmm.15235

PMID: 32285594


TRR259_Logo_Rund_TransparentBasic Biology of Extracellular Matrix in the Cardiovascular System

Del Monte-Nieto G, Fischer JW, Gorski DJ, Harvey RP, Kovacic JC.

Part 1/4 JACC Focus Seminar. J Am Coll Cardiol, 75 (17) 2169–2188 doi:10.1016/j.jacc.2020.03.024 


TRR259_Logo_Rund_TransparentNew Insights into the Regulation of Apoptosis, Necroptosis, and Pyroptosis by Receptor Interacting Protein Kinase 1 and Caspase-8

Robin Schwarzer, Lucie Laurien, and Manolis Pasparakis

Current Opinion in Cell Biology, 2020 April, 63:186–93. https://doi.org/10.1016/j.ceb.2020.02.004


In vivo detection of programmed cell death during mouse heart development

Kristel Martínez-Lagunas, Yoshifumi Yamaguchi, Cora Becker, Caroline Geisen, Marco C. DeRuiter, Masayuki Miura, Bernd K. Fleischmann and Michael Hesse

Cell Death & Differentiation 2020 Apr; 27(4):1398-1414, DOI: 10.1038/s41418-019-0426-2

PMID: 31570857



TRR259_Logo_Rund_TransparentAortic Valve Stenosis – From Basic Mechanisms to Novel Therapeutic Targets

Philip Roger Goody, Mohammed Rabiul Hosen, Dominik Christmann, Sven Thomas Niepmann, Andreas Zietzer, Matti Adam, Florian Bönner, Sebastian Zimmer, Georg Nickenig, Felix Jansen

Arteriosclerosis, Thrombosis, and Vascular Biology 2020 Apr;40(4):885–900; DOI: 10.1161/ATVBAHA.119.313067

PMID: 32160774


High-Sensitivity Troponin T Testing: Consequences on Daily Clinical Practice and Effects on Diagnosis of Myocardial Infarction

Christian Frédéric Zachoval, Ramona Dolscheid-Pommerich, Ingo Graeff, Bernd Goldschmidt, Andreas Grigull, Birgit Stoffel-Wagner, Georg Nickenig, Sebastian Zimmer 

J Clin Med. 2020 Mar 12;9(3):775. doi: 10.3390/jcm9030775.

PMCID: PMC7141275


TRR259_Logo_Rund_TransparentBMPR2 acts as a gatekeeper to protect endothelial cells from increased TGFβ responses and altered cell mechanics

Christian Hiepen, Jerome Jatzlau, Susanne Hildebrandt, Branka Kampfrath, Melis Goktas, Arunima Murgai, Jose Luis Cuellar Camacho, Rainer Haag, Clemens Ruppert, Gerhard Sengle, Elisabetta Ada Cavalcanti-Adam, Kerstin G. Blank, Petra Knaus

PLOS Biology 17(12): e3000557. https://doi.org/10.1371/journal.pbio.3000557


Intravascular Lithotripsy in Calcified Coronary Lesions: A Prospective, Observational, Multicenter Registry

Adem Aksoy, Carlos Salazar, Marc Ulrich Becher, Vedat Tiyerili, Marcel Weber, Felix Jansen, Alexander Sedaghat, Sebastian Zimme, Jürgen Leick, Eberhard Grube, Nieves Gonzalo, Jan-Malte Sinning, Javier Escaned, Georg Nickenig, Nikos Werner

 

Circ Cardiovasc Interv. 2019 Nov;12(11):e008154. DOI: 10.1161/CIRCINTERVENTIONS.119.008154.

 

PMID: 31707803


TRR259_Logo_Rund_TransparentHDAC9 is implicated in atherosclerotic aortic calcification and affects vascular smooth muscle cell phenotype

 

Malhotra, R., Mauer, A.C., Lino Cardenas, C.L. et al. 

 

Nat Genet, 2019 Oct 28, 51, 1580–1587 (2019). https://doi.org/10.1038/s41588-019-0514-8


TRR259_Logo_Rund_TransparentOf Vesicles and Viruses - Why Statins Are Good for HIV Patients

Philip Roger Goody, Felix Jansen, Georg Nickenig

Circulation Research, 2019 Oct 10; 125:821-823. https://doi.org/10.1161/CIRCRESAHA.119.315908


Graded Murine Wire-Induced Aortic Valve Stenosis Model Mimics Human Functional and Morphological Disease Phenotype

 

Sven Thomas Niepmann, Eva Steffen, Andreas Zietzer, Matti Adam, Julia Nordsiek, Isabella Gyamfi-Poku, Kerstin Piayda, Jan-Malte Sinning, Stephan Baldus, Malte Kelm, Georg Nickenig, Sebastian Zimmer, Christine Quast

 

Clin Res Cardiol. 2019 Aug;108(8):847-856. DOI: 10.1007/s00392-019-01413-1.

 

PMID: 30767058

 


cGMP manipulation in cardiometabolic disease: chances and challenges.

Jens Jordan, Staffan Hildebrand, Alexander Pfeifer


Curr Opin Cardiol. 2019 Juli;34(4):376-383. DOI:10.1097/HCO.0000000000000630

 

PMID: 30994530


 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

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