TRR259 - Aortic Disease
University of Bonn
TRR259 - Aortic Disease
University of Cologne
TRR259 - Aortic Disease
University of Düsseldorf
TRR259 - Aortic Disease
TRR259 - Aortic Disease
TRR259 - Aortic Disease

About us

The TRR259 is a Collaborative Research Center funded by the German Research Foundation (DFG) at the University Bonn, Cologne, and Düsseldorf. In a joint and multidisciplinary effort, we are investigating the molecular and cellular mechanisms of aortic disease holistically, with a particular focus on aortic valve stenosis, aortic aneurysm, and aortic dissection. Prospectively, we envision identifying novel pharmacological, interventional, and surgical targets for diagnostic, preventive, and therapeutic strategies within the frame of translational and clinical studies. 

Governance

Get to know the speakers and committee members of the TRR259

Coordination Office

Get in touch with our coordinators from the three different universities

Scientific Advisory Board

Get to know the five members of our Scientific Advisory Board

Members of the TRR259

Here you will find a list of all project leaders from the TRR259

Partners

Find information about our partners

Eine Wissenschaftlerin und ein Wissenschaftler arbeiten hinter einer Glasfassade und mischen Chemikalien mit Großgeräten.
© COLOURBOX_cb_24473548

Summary of the Collaborative Research Center project plan:

The aorta is composed of the aortic valve, the ascending aorta with its root and arch, as well as the thoracic and abdominal sections of the descending aorta. It connects the heart with the peripheral circulation and organs, and it is involved in the complex regulation of hemodynamics. Although each section of the aorta has a unique composition, is exposed to distinct mechanical forces, and therefore, develops specific disease phenotypes, different aortic disorders share some of the same pathophysiological mechanisms: biological, chemical, and mechanical stressors promote dysfunction of the aortic endothelial lining, recruitment and activation of immune cells, and subsequent modification of interstitial cell metabolism. This local proinflammatory milieu stimulates an increased and faulty deposition of extracellular matrix, posttranslational matrix remodeling, and premature calcification as a critical prerequisite for aortic wall or valve injury. There are two apparent sources for these effects: resident factors and circulating, non-resident factors. Within the aorta itself, resident effectors include oxidative and mechanical stress, as well as modulation of endothelial and interstitial cells and the extracellular matrix. In addition, there are a number of non-resident factors that contribute to aortic disease, including immune cells, platelets, fat cells, and various signaling molecules. An individual’s susceptibility for developing disease is largely determined by a, yet unclear, genetic predisposition. While aortic diseases occur frequently, are associated with high mortality, and often require hazardous interventions, the distinct pathologies of the aortic system have never been systematically investigated. The interconnection and mutual impact of aortic diseases on each other within the complex aortic system remains obscured.

With this initiative, we aim to address the underlying resident and non-resident molecular and cellular mechanisms of aortic disease in a holistic manner, with a particular focus on aortic valve stenosis, aortic aneurysm, and aortic dissection. Prospectively, we envision identifying novel pharmacological, interventional, and surgical targets for diagnostic, preventive, and therapeutic strategies within the frame of translational and clinical studies.

Clustered along the Rhine River, the three universities involved in the Aortic Disease CRC/Transregio proposal are bringing together basic and clinical science experts, and will fill a gap that currently exists in cardiovascular research. This collaboration has positioned the three institutions perfectly to investigate the causes of aortic disease, and hopefully in further funding periods, to begin to move towards new treatment regimens.

The most common aortic diseases are aortic valve stenosis, thoracic and abdominal aneurysms, and aortic dissection
© Sebastian Zimmer

Contact

Avatar Enders

Dr. Marika Enders

Scientific coordinator of the TRR259

Biomedical Center I Building 13, 3G, room 022

Venusberg-Campus 1

53127 Bonn

+49 228 287-51735

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