Publications of the TRR259 - 2022
Deleting interleukin-10 from myeloid cells exacerbates atherosclerosis in Apoe-/- mice
Orecchioni M, Wolf D, Suryawanshi V, Winkels H, Kobiyama K, Makings J, Kiosses WB, Ley K
Cell Mol Life Sci. 2022 Dec 10;80(1):10. doi: 10.1007/s00018-022-04649-9.
Translational opportunities of single-cell biology in atherosclerosis
de Winther MPJ, Bäck M, Evans P, Gomez D, Goncalves I, Jørgensen HF, Koenen RR, Lutgens E, Norata GD, Osto E, Dib L, Simons M, Stellos K, Ylä-Herttuala S, Winkels H, Bochaton-Piallat ML, Monaco C.
Eur Heart J. 2022 Dec 7:ehac686. doi: 10.1093/eurheartj/ehac686.
Poly(I:C) treatment prevents skin tumor formation in the preclinical HPV8 transgenic mouse model
Hufbauer M, Rattay S, Hagen C, Quaas A, Pfister H, Hartmann G, Coch C, Akgül B.
J Invest Dermatol. 2022 Dec 27:S0022-202X(22)02900-1. doi: 10.1016/j.jid.2022.12.007.
Deleting interleukin-10 from myeloid cells exacerbates atherosclerosis in Apoe-/- mice
Orecchioni M, Wolf D, Suryawanshi V, Winkels H, Kobiyama K, Makings J, Kiosses WB, Ley K.
Cell Mol Life Sci. 2022 Dec 10;80(1):10. doi: 10.1007/s00018-022-04649-9.
Hemodynamics of self-expanding versus balloon-expandable transcatheter heart valves in relation to native aortic annulus anatomy.
Schmidt S, Fortmeier V, Ludwig S, Wienemann H, Körber MI, Lee S, Meertens M, Macherey S, Iliadis C, Kuhn E, Eghbalzadeh K, Bleiziffer S, Baldus S, Schofer N, Rudolph TK, Adam M, Mauri V
Clin Res Cardiol. 2022 Dec;111(12):1336-1347. doi: 10.1007/s00392-022-02046-7.
Myeloperoxidase is a Critical Mediator of Anthracycline-induced Cardiomyopathy
Felix Sebastian Nettersheim, Johannes David Schlüter, Wiebke Kreuzberg et al.
13 December 2022, PREPRINT (Version 1) available at Research Square [https://doi.org/10.21203/rs.3.rs-2219349/v1]
Vascular ultrasound for in vivo assessment of arterial pathologies in a murine model of atherosclerosis and aortic aneurysm
Hof A, Guthoff H, Ahdab M, Landerer M, Schäkel J, Niehues J, Schorscher M, Winkels H, Geißen S, Adam M, Mollenhauer M, Mehrkens D.
bioRxiv 2022:2022.12.22.521641. doi:10.1101/2022.12.22.521641.
Echocardiographic progression of calcific aortic valve disease in patients with preexisting aortic valve sclerosis
Shamekhi J, Uehre C, Al-Kassou B, Weber M, Sugiura A, Wilde N, Mauri V, Veulemans V, Kelm M, Baldus S, Nickenig G, Zimmer S.
medRxiv 2022.12.02.22283035. doi:10.1101/2022.12.02.22283035.
Using TCR and BCR sequencing to unravel the role of T and B cells in abdominal aortic aneurysm
Elster C, Ommer-Bläsius M, Lang A, Vajen T, Pfeiler S, Feige M, Quy KL, Chernigovskaya M, Kelm M, Winkels H, Schmidt SV, Greiff V, Gerdes N
bioRxiv 2022.12.01.518788. doi:10.1101/2022.12.01.518788.
Ionizing radiation improves RIG-I mediated immunotherapy through enhanced p53 activation in malignant melanoma
Lambing S, Holdenrieder S, Müller P, Hagen C, Garbe S, Schlee M, van den Boorn JG, Bartok E, Hartmann G, Renn M.
BioRxiv 2021:2021.10.16.464638. doi:10.1101/2021.10.16.464638.
PI 3-kinase isoform p110alpha controls smooth muscle cell functionality and protects against aortic aneurysm formation.
Vantler M, Schorscher M, Berghausen EM, Moore JB, Wong D, Zhaolong L, Wissmueller M, Gnatzy-Feik L, Zierden M, Mehrkens D, Adam M, Zhao X, Odenthal M, Sengle G, Boor P, Maegdefessel L, Baldus S, Rosenkranz S.
bioRxiv 2022.12.01.518561. doi:10.1101/2022.12.01.518561.
Aortic valve stenosis induced occult hemoglobin release promotes endothelial dysfunction
Quast C, Boenner F, Polzin A, Veulemans V, Poku IG, Chennupati R, Nankinova M, Staub N, Jokiel J, Keyser F, Hoffe J, Becker K, Leuders P, Zako S, Erkens R, Jung C, Floegel U, Neidlin M, Steinseifer U, Niepmann ST, Zimmer S, Feelisch M, Zeus T, Kelm M
medRxiv 2022.12.01.22282891. doi:10.1101/2022.12.01.22282891.
Fibrillin microfibril structure identifies long-range effects of inherited pathogenic mutations affecting a key regulatory TGFβ-binding site
Godwin AR, Thomson J, Holmes D, Adamo C, Sengle G, Sherratt M, Roseman A, Baldock C
BioRxiv 2022.08.26.505362. doi:10.1101/2022.08.26.505362.
Porcine and human aortic valve endothelial and interstitial cell isolation and characterization
Nehl D, Goody PR, Maus K, Pfeifer A, Aikawa E, Bakhtiary F, Zimmer S, Nickenig G, Jansen F, Hosen MR
bioRxiv 2022:2022.12.01.518669. doi:10.1101/2022.12.01.518669.
Platelets modulate inflammation and matrix remodeling in abdominal aortic aneurysm
Wagenhaeuser MU, Mulorz J, Krott KJ, Feige T, Ehrenberg A, Rhee YH, Chatterjee M, Petzold N, Boeddeker C, Ibing W, Krueger I, Spin JM, Tsao PS, Roseman A, Schelzig H, Elvers M.
bioRxiv 2022.12.01.518674. doi:10.1101/2022.12.01.518674.
Deficiency in hyaluronan synthase 3 attenuates ruptures in a murine model of abdominal aortic aneurysms by reduced aortic monocyte infiltration
Suvorava T*, Brack F*, Kaczur J, Petzsch P, Köhrer K, Quast C, Gerdes N, Voigt K, Krüger M, Fischer W, Brückner A, Fleischmann BK, Wenzel D, Zimmermann L-M A, Sengle G, Flögel U, Grandoch M
bioRxiv 2022.12.01.518480, doi:10.1101/2022.12.01.518480.
Targeting of MMP-13 prevents aortic aneurysm formation in Marfan mice
Zimmermann L-MA, Furlan AG, Mehrkens D, Geissen S, Zuk AV, Pryymachuk G, Pykarek N, Beers T van, Sonntag-Bensch D, Marzi J, Schenke-Layland K, Brinckmann J, Grandoch M, Zigrino P, Baldus S, Sengle G
bioRxiv 2022.11.30.518511. doi:10.1101/2022.11.30.518511.
Aortic valve disease augments vesicular microRNA-145-5p to regulate the calcification of valvular interstitial cells via cellular crosstalk
Goody PR, Christmann D, Goody D, Nehl D, Backer K, Wilhelm-Juengling K, Uchida S, Moore JB, Zimmer S, Bakhtiary F, Pfeifer A, Latz E, Nickenig G, Jansen F, Hosen MR.
bioRxiv 2022:2022.11.29.518326. doi:10.1101/2022.11.29.518326.
RIG-I activation primes and trains innate antiviral immune memory
Adamson MS, Nesic S, Buness A, Bayrak K, Schmitz S, Soler S, Zillinger T, Marx S, Lambing S, Andryka-Cegielski K, Khan F, Schlee-Guimarães TM, Herberhold S, Proietti M, Placek K, Reading P, Cicin-Sain L, Schlee M, Boorn J van den, Hartmann E, Hartmann G, Bartok E.
bioRxiv 2022.10.27.514004. doi:10.1101/2022.10.27.514004.
Platelet pannexin-1 channels modulate inflammation during abdominal aortic aneurysm formation
Metz LM, Feige T, de Biasi L, Ehrenberg A, Mulorz J, Toska LM, Reusswig F, Quast C, Gerdes N, Kelm M, Schelzig H, Elvers M.
bioRxiv 2022.11.23.517652; doi: https://doi.org/10.1101/2022.11.23.517652.
Inhibition of MLKL impairs abdominal aortic aneurysm development by attenuating smooth muscle cell necroptosis
Nemade HN, Mehrkens D, Lottermoser HS, Yilmaz ZE, Schelemei P, Picard FR, Geißen S, Schwab GF, Hoyer FF, Guthoff H, Hof A, Nettersheim FS, Sachinidis A, Winkels H, Baldus S, Pasparakis M, Adam M, Mollenhauer M.
bioRxiv 2022.11.24.517638. doi:10.1101/2022.11.24.517638.
Inhibition of myeloperoxidase attenuates thoracic aortic aneurysm formation in Marfan disease
Mehrkens D, Nettersheim FS, Ballmann F, Bastigkeit J, Brückner A, Dohr J, Geissen S, Vore LD, Schelemei P, Picard FR, Kochen M, Braumann S, Kreuzberg W, Hof A, Guthoff H, Brandtner A, Mensah BQ, Groenink M, Andel M van, Mieremet A, Pfeiler S, Gerdes N, Flögel U, Zimmermann L-M, Sengle G, Eich M-L, Schömig-Mariefka B, Adam M, Fleischmann BK, Wenzel D, Waard V de, Klinke A, Baldus S, Mollenhauer M, Winkels H.
bioRxiv 2022.11.24.517172. doi:10.1101/2022.11.24.517172.
Quantitative assessment of angioplasty induced vascular inflammation with 19F cardiovascular magnetic resonance imaging
Nienhaus F, Walz M, Rothe M, Jahn A, Pfeiler S, Busch HL, Stern M, Heiss C, Vornholz L, Cames S, Cramer M, Schrauwen-Hinderling V, Gerdes N, Temme S, Roden M, Floegel U, Kelm M, Boenner F.
bioRxiv 2022.11.25.518014. doi:10.1101/2022.11.25.518014.
A simplified cardiac damage staging predicts the outcome of patients undergoing TAVR-A multicenter analysis
Shamekhi J, Hasse C, Veulemans V, Al-Kassou B, Piayda K, Maier O, Zeus T, Weber M, Sedaghat A, Zimmer S, Kelm M, Nickenig G, Sinning JM.
Catheter Cardiovasc Interv. 2022 Nov;100(5):850-859. doi: 10.1002/ccd.30368.
A Novel Model to Predict 1-Year Mortality in Elective Transfemoral Aortic Valve Replacement: The TAVR-Risk Score
Jung C, Fujita B, Feldt K, Wernly B, Bruno RR, Wolff G, Zeus T, Polzin A, Lichtenberg A, Beyersdorf F, Bauer T, Bekeredjian R, Bleiziffer S, Beckmann A, Frerker C, Möllmann H, Walther T, Gummert J, Zeiher A, Hamm C, Meduri CU, Settergren M, Kelm M, Ensminger S.
J Invasive Cardiol. 2022 Nov;34(11):E776-E783. Epub 2022 Oct 13. PMID: 36227011
E-cigarette exposure augments murine abdominal aortic aneurysm development: role of Chil1
Mulorz J, Spin JM, Mulorz P, Wagenhäuser M, Deng A, Mattern K, Rhee YH, Toyama K, Adam M, Schelzig H, Maegdefessel L, Tsao PS.
Cardiovasc Res. 2022 Nov 22:cvac173. doi: 10.1093/cvr/cvac173.
EMILIN1 deficiency causes arterial tortuosity with osteopenia and connects impaired elastogenesis with defective collagen fibrillogenesis.
Adamo CS, Beyens A, Schiavinato A, Keene DR, Tufa SF, Mörgelin M, Brinckmann J, Sasaki T, Niehoff A, Dreiner M, Pottie L, Muiño-Mosquera L, Gulec EY, Gezdirici A, Braghetta P, Bonaldo P, Wagener R, Paulsson M, Bornaun H, De Rycke R, De Bruyne M, Baeke F, Devine WP, Gangaram B, Tam A, Balasubramanian M, Ellard S, Moore S, Symoens S, Shen J, Cole S, Schwarze U, Holmes KW, Hayflick SJ, Wiszniewski W, Nampoothiri S, Davis EC, Sakai LY, Sengle G, Callewaert B.
The American Journal of Human Genetics 2022. doi:10.1016/j.ajhg.2022.10.010. (10,502 original article)
Innate sensing of mRNA vaccines
Wuebben C, Bartok E, Hartmann G.
Curr Opin Immunol. 2022 Oct 27;79:102249. doi: 10.1016/j.coi.2022.102249.
Fatty Acid Amide Hydrolase Deficiency Is Associated with Deleterious Cardiac Effects after Myocardial Ischemia and Reperfusion in Mice
Rajlic S, Surmann L, Zimmermann P, Weisheit CK, Bindila L, Treede H, Velten M, Daiber A, Duerr GD
Int J Mol Sci. 2022 Oct 21;23(20):12690. doi: 10.3390/ijms232012690.
Therapie der Aortenklappenstenose jenseits des Klappenersatzes – Was bringt die Zukunft?
Billig H, Goody P, Nickenig G
Aktuelle Kardiologie 2022;11:434–443. doi:10.1055/a-1842-3378.
EMILIN1 deficiency causes arterial tortuosity with osteopenia and connects impaired elastogenesis with defective collagen fibrillogenesis
Adamo CS, Beyens A, Schiavinato A, Keene DR, Tufa SF, Mörgelin M, Brinckmann J, Sasaki T, Niehoff A, Dreiner M, Pottie L, Muiño-Mosquera L, Gulec EY, Gezdirici A, Braghetta P, Bonaldo P, Wagener R, Paulsson M, Bornaun H, De Rycke R, De Bruyne M, Baeke F, Devine WP, Gangaram B, Tam A, Balasubramanian M, Ellard S, Moore S, Symoens S, Shen J, Cole S, Schwarze U, Holmes KW, Hayflick SJ, Wiszniewski W, Nampoothiri S, Davis EC, Sakai LY, Sengle G, Callewaert B
The American Journal of Human Genetics 2022. doi:10.1016/j.ajhg.2022.10.010
Optimal protamine-to-heparin dosing ratio for the prevention of bleeding complications in patients undergoing TAVR-A multicenter experience
Al-Kassou B, Veulemans V, Shamekhi J, Maier O, Piayda K, Zeus T, Aksoy A, Zietzer A, Meertens M, Mauri V, Weber M, Sinning JM, Grube E, Adam M, Bakhtiary F, Zimmer S, Baldus S, Kelm M, Nickenig G, Sedaghat A
Clin Cardiol. 2022 Oct 19. doi: 10.1002/clc.23936. Epub ahead of print
Monocyte-derived macrophages aggravate pulmonary vasculitis via cGAS/STING/IFN-mediated nucleic acid sensing
Kessler N, Viehmann SF, Krollmann C, Mai K, Kirschner KM, Luksch H, Kotagiri P, Böhner AMC, Huugen D, de Oliveira Mann CC, Otten S, Weiss SAI, Zillinger T, Dobrikova K, Jenne DE, Behrendt R, Ablasser A, Bartok E, Hartmann G, Hopfner KP, Lyons PA, Boor P, Rösen-Wolff A, Teichmann LL, Heeringa P, Kurts C, Garbi N
J Exp Med. 2022 Oct 3;219(10):e20220759. doi: 10.1084/jem.20220759. Epub 2022 Aug 23. PMID: 35997679.
Ceramide Metabolism in Cardiovascular Disease: A Network With High Therapeutic Potential
Zietzer A, Düsing P, Reese L, Nickenig G, Jansen F.
Arterioscler Thromb Vasc Biol. 2022 Aug 25:101161ATVBAHA122318048. doi: 10.1161/ATVBAHA.122.318048. Epub ahead of print. PMID: 36004640.
Extracellular Vesicle Separation Techniques Impact Results from Human Blood Samples: Considerations for Diagnostic Applications
Tzaridis T, Bachurski D, Liu S, Surmann K, Babatz F, Gesell Salazar M, Völker U, Hallek M, Herrlinger U, Vorberg I, Coch C, Reiners KS, Hartmann G.
Int J Mol Sci. 2021 Aug 26;22(17):9211. doi: 10.3390/ijms22179211.
The lncRNA MRPL20-AS1 is associated with severe OSAS and downregulated upon hypoxic injury of endothelial cells
Zietzer A, Breitrück N, Düsing P, Böhle S, Klussmann JP, Al-Kassou B, Goody PR, Hosen MR, Nickenig G, Nachtsheim L, Shabli S, Jansen F, Jansen S.
Int J Cardiol. 2022 Aug 18:S0167-5273(22)01202-5. doi: 10.1016/j.ijcard.2022.08.035. Epub ahead of print. PMID: 35988669.
Temporal trends of TAVI treatment characteristics in high volume centers in Germany 2013-2020
Mauri V, Abdel-Wahab M, Bleiziffer S, Veulemans V, Sedaghat A, Adam M, Nickenig G, Kelm M, Thiele H, Baldus S, Rudolph TK
Clin Res Cardiol. 2022 Aug;111(8):881-888. doi: 10.1007/s00392-021-01963-3. Epub 2021 Nov 9. PMID: 34751789; PMCID: PMC9334359.
Smooth muscle cell specific NEMO deficiency inhibits atherosclerosis in ApoE-/- mice
Imai T, Van TM, Pasparakis M, Polykratis A
Sci Rep. 2022 Jul 22;12(1):12538. doi: 10.1038/s41598-022-16737-8. PMID: 35869246; PMCID: PMC9307802.
Predictive value of the Fibrosis-4 index in patients with severe aortic stenosis undergoing transcatheter aortic valve replacement
Sudo M, Shamekhi J, Sedaghat A, Aksoy A, Zietzer A, Tanaka T, Wilde N, Weber M, Sinning JM, Grube E, Veulemans V, Adam M, Kelm M, Baldus S, Nickenig G, Zimmer S, Tiyerili V, Al-Kassou B
Clin Res Cardiol. 2022 Jul 19. doi: 10.1007/s00392-022-02055-6. Epub ahead of print. PMID: 35852581.
Myeloid leukocytes' diverse effects on cardiovascular and systemic inflammation in chronic kidney disease
Hof A, Geißen S, Singgih K, Mollenhauer M, Winkels H, Benzing T, Baldus S, Hoyer FF
2022 Jul 27;117(1):38. doi: 10.1007/s00395-022-00945-4.
3D-speckle-tracking echocardiography correlates with cardiovascular magnetic resonance imaging diagnosis of acute myocarditis - An observational study
Goody PR, Zimmer S, Öztürk C, Zimmer A, Kreuz J, Becher MU, Isaak A, Luetkens J, Sugiura A, Jansen F, Nickenig G, Hammerstingl C, Tiyerili V
Int J Cardiol Heart Vasc. 2022 Jul 12;41:101081. doi: 10.1016/j.ijcha.2022.101081
Innate immune receptor signaling induces transient melanoma dedifferentiation while preserving immunogenicity
Thier B, Zhao F, Stupia S, Brüggemann A, Koch J, Schulze N, Horn S, Coch C, Hartmann G, Sucker A, Schadendorf D, Paschen A.
J Immunother Cancer. 2022 Jun;10(6):e003863. doi: 10.1136/jitc-2021-003863.
Human Beta Papillomavirus Type 8 E1 and E2 Proteins Suppress the Activation of the RIG-I-Like Receptor MDA5
Rattay S, Hufbauer M, Hagen C, Putschli B, Coch C, Akgül B, Hartmann G
Viruses. 2022 Jun 22;14(7):1361. doi: 10.3390/v14071361.
Multi-Slice Computed Tomography Analysis in Patients Undergoing Transcatheter Aortic Valve Replacement - Impact of Workflows on Measurement of Virtual Aortic Annulus and Valve Size
Piayda K, Hellhammer K, Veulemans V, Afzal S, Klein K, Berisha N, Leuders P, Erkens R, Kirchner J, Heidari H, Kelm M, Antoch G, Zeus T, Quast C
Front Cardiovasc Med. 2022 Jun 21;9:877511. doi: 10.3389/fcvm.2022.877511. PMID: 35800172; PMCID: PMC9253507
Modulation of mTOR Signaling in Cardiovascular Disease to Target Acute and Chronic Inflammation
Kaldirim M, Lang A, Pfeiler S, Fiegenbaum P, Kelm M, Bönner F, Gerdes N
Front Cardiovasc Med. 2022 Jun 29;9:907348. doi: 10.3389/fcvm.2022.907348
Apoptotic brown adipocytes enhance energy expenditure via extracellular inosine.
Niemann B, Haufs-Brusberg S, Puetz L, Feickert M, Jaeckstein MY, Hoffmann A, Zurkovic J, Heine M, Trautmann E-M, Müller CE, Tönjes A, Schlein C, Jafari A, Eltzschig HK, Gnad T, Blüher M, Krahmer N, Kovacs P, Heeren J, Pfeifer A
Nature 2022:1–3. doi:10.1038/s41586-022-05041-0.
Circulating MicroRNA-122-5p Is Associated With a Lack of Improvement in Left Ventricular Function After Transcatheter Aortic Valve Replacement and Regulates Viability of Cardiomyocytes Through Extracellular Vesicles
Hosen MR, Goody PR, Zietzer A, Xiang X, Niepmann ST, Sedaghat A, Tiyerili V, Chennupati R, Moore JB, Boon RA, Uchida S, Sinning J-M, Zimmer S, Latz E, Werner N, Nickenig G, Jansen F
Circulation 2022;146:00-000. doi:10.1161/CIRCULATIONAHA.122.060258.
Hemodynamics of self-expanding versus balloon-expandable transcatheter heart valves in relation to native aortic annulus anatomy
Schmidt S, Fortmeier V, Ludwig S, Wienemann H, Körber MI, Lee S, Meertens M, Macherey S, Iliadis C, Kuhn E, Eghbalzadeh K, Bleiziffer S, Baldus S, Schofer N, Rudolph TK, Adam M, Mauri V.
Clin Res Cardiol. 2022 Jun 15. doi: 10.1007/s00392-022-02046-7. Epub ahead of print. PMID: 35704088.
Elucidation of the genetic causes of bicuspid aortic valve disease
Gehlen J, Stundl A, Debiec R, Fontana F, Krane M, Sharipova D, Nelson CP, Al-Kassou B, Giel AS, Sinning JM, Bruenger CM, Zelck CF, Koebbe LL, Braund PS, Webb TR, Hetherington S, Ensminger S, Fujita B, Mohamed SA, Shrestha M, Krueger H, Siepe M, Kari FA, Nordbeck P, Buravezky L, Kelm M, Veulemans V, Adam M, Baldus S, Laugwitz KL, Haas Y, Karck M, Mehlhorn U, Conzelmann LO, Breitenbach I, Lebherz C, Urbanski P, Kim WK, Kandels J, Ellinghaus D, Nowak-Goettl U, Hoffmann P, Wirth F, Doppler S, Lahm H, Dreßen M, von Scheidt M, Knoll K, Kessler T, Hengstenberg C, Schunkert H, Nickenig G, Nöthen MM, Bolger AP, Abdelilah-Seyfried S, Samani NJ, Erdmann J, Trenkwalder T, Schumacher J.
Cardiovasc Res. 2022 Jun 21:cvac099. doi: 10.1093/cvr/cvac099. Epub ahead of print. PMID: 35727948.
BMP antagonists in tissue development and disease
Correns A, Zimmermann LA, Baldock C, Sengle G.
Matrix Biol Plus. 2021 Jun 11;11:100071. doi: 10.1016/j.mbplus.2021.100071.
Myeloid CD40 deficiency reduces atherosclerosis by impairing macrophages' transition into a pro-inflammatory state
Bosmans LA, van Tiel CM, Aarts SABM, Willemsen L, Baardman J, van Os BW, den Toom M, Beckers L, Ahern DJ, Levels JHM, Jongejan A, Moerland PD, Verberk SGS, van den Bossche J, de Winther MMPJ, Weber C, Atzler D, Monaco C, Gerdes N, Shami A, Lutgens E
Cardiovasc Res. 2022 May 19:cvac084. doi: 10.1093/cvr/cvac084. Epub ahead of print.
PMID: 35587037.
Multiparametric MRI identifies subtle adaptations for demarcation of disease transition in murine aortic valve stenosis
Quast, C., Kober, F., Becker, K. et al.
Basic Res Cardiol 117, 29 (2022). https://doi.org/10.1007/s00395-022-00936-5
FGF21 modulates mitochondrial stress response in cardiomyocytes only under mild mitochondrial dysfunction
Croon M, Szczepanowska K, Popovic M, Lienkamp C, Senft K, Brandscheid CP, Bock T, Gnatzy-Feik L, Ashurov A, Acton RJ, Kaul H, Pujol C, Rosenkranz S, Krüger M, Trifunovic A.
Sci Adv. 2022 Apr 8;8(14):eabn7105. doi: 10.1126/sciadv.abn7105.
Regional analysis of inflammation and contractile function in reperfused acute myocardial infarction by in vivo 19F cardiovascular magnetic resonance in pigs
Bönner F, Gastl M, Nienhaus F, Rothe M, Jahn A, Pfeiler S, Gross U, Schultheiss HP, Ibanez B, Kozerke S, Szendroedi J, Roden M, Westenfeld R, Schrader J, Flögel U, Heusch G, Kelm M
Basic Res Cardiol. 2022 Apr 7;117(1):21. doi: 10.1007/s00395-022-00928-5. PMID: 35389088; PMCID: PMC8989832.
EBI2 is a negative modulator of brown adipose tissue energy expenditure in mice and human brown adipocytes.
Copperi F, Schleis I, Roumain M, Muccioli GG, Casola S, Klingenspor M, Pfeifer A, Gnad T.
Commun Biol. 2022 Mar 29;5(1):280. doi: 10.1038/s42003-022-03201-6. PMID: 35351968
Methods for the identification and characterization of extracellular vesicles in cardiovascular studies - from exosomes to microvesicles
Davidson SM, Boulanger CM, Aikawa E, Badimon L, Barile L, Binder CJ, Brisson A, Buzas E, Emanueli C, Jansen F, Katsur M, Lacroix R, Lim SK, Mackman N, Mayr M, Menasché P, Nieuwland R, Sahoo S, Takov K, Thum T, Vader P, Wauben MHM, Witwer K, Sluijter JPG
Cardiovasc Res. 2022 Mar 24:cvac031. doi: 10.1093/cvr/cvac031. Epub ahead of print. PMID: 35325061
Renal Denervation Prevents Atrial Arrhythmogenic Substrate Development in CKD
Hohl M, Selejan SR, Wintrich J, Lehnert U, Speer T, Schneider C, Mauz M, Markwirth P, Wong DWL, Boor P, Kazakov A, Mollenhauer M, Linz B, Klinkhammer BM, Hübner U, Ukena C, Moellmann J, Lehrke M, Wagenpfeil S, Werner C, Linz D, Mahfoud F, Böhm M.
Circ Res. 2022 Mar 18;130(6):814-828. doi: 10.1161/CIRCRESAHA.121.320104. Epub 2022 Feb 8. PMID: 35130718.
Aortenerkrankungen
JGoody, P.R., Baldus, S., Kelm, M. et al.
Kardiologe 16, 92–99; 2022 Mar 17. https://doi.org/10.1007/s12181-022-00539-3
RIG-I-induced innate antiviral immunity protects mice from lethal SARS-CoV-2 infection
Marx S, Kümmerer BM, Grützner C, Kato H, Schlee M, Renn M, Bartok E, Hartmann G.
Mol Ther Nucleic Acids. 2022 Mar 8;27:1225-1234. doi: 10.1016/j.omtn.2022.02.008. Epub 2022 Feb 13. PMID: 35186439; PMCID: PMC8841011.
Analysis of nocturnal, hypoxia-induced miRNAs in sleep apnea patients
Goody PR, Nachtsheim L, Hosen MR, von Krosigk M, Christmann D, Klussmann JP, Zietzer A, Breitrück N, Jansen F, Jansen S.
PLoS One. 2022 Mar 4;17(3):e0263747. doi: 10.1371/journal.pone.0263747. PMID: 35245292; PMCID: PMC8896679.
PDGF regulates guanylate cyclase expression and cGMP signaling in vascular smooth muscle.
Hildebrand S, Ibrahim M, Schlitzer A, Maegdefessel L, Röll W, Pfeifer A.
Commun Biol. 2022 Mar 3;5(1):197. doi: 10.1038/s42003-022-03140-2. PMID: 35241778
Smart devices resulting in big effect: can apps cure heart disease?
Eckardt I, Düsing P, Nickenig G, Jansen F.
Eur Heart J. 2022 Feb 3:ehab917. doi: 10.1093/eurheartj/ehab917. Epub ahead of print. PMID: 35134887.
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