Publications of the TRR259 - 2025
Generation of a homozygous DNMT3A knock-out hiPSC line for modeling of cardiovascular diseases associated with clonal hematopoiesis of indeterminate potential.
Triantafyllou C, Peitz M, Fleischmann BK, Rieck S.
Stem Cell Res. 2025 Aug;86:103707. doi: 10.1016/j.scr.2025.103707.
Generation of a genome-edited EMILIN1 (c.1606C>T) hiPSC line to investigate aortic aneurysm formation in vitro.
Zhang Y, Peitz M, Fleischmann BK, Rieck S.
Stem Cell Res. 2025 Aug;86:103708. doi: 10.1016/j.scr.2025.103708.
Implications of monogenic bicuspid aortic valve (BAV) forms among sporadic BAV patients.
Bruenger CMH, Oeffner F, Koebbe LL, Zimmer S, Veulemans V, Adam M, Bigge J, Heilmann-Heimbach S, Kelm M, Baldus S, Nöthen MM, Nickenig G, Maj C, Al-Kassou B, Schumacher J.
Eur J Hum Genet. 2025 Jul 11. doi: 10.1038/s41431-025-01909-7.
Valvular Endothelial Cell Heterogeneity Reflects Different Pathogenesis of Tricuspid and Bicuspid Aortic Valve Stenosis in Humans.
Brandtner A, Brückner A, Röll W, Bakhtiary F, Fleischmann BK, Wenzel D.
J Am Heart Assoc. 2025 Jul;14(13):e040556. doi: 10.1161/JAHA.124.040556.
Theranostic Toolbox for Neutrophil Functionalization.
Bouvain P, Thomy KM, Prinz AM, Steckel B, Kadir S, Röhs A, Schmitz J, Dohle C, Karg M, Grandoch M, Flögel U, Temme S.
Adv Sci (Weinh). 2025 Jun 30:e04412. doi: 10.1002/advs.202504412.
Prevalence and Management of Multiple Valvular Heart Disease in Patients Undergoing Transcatheter Aortic Valve Replacement: A Multicenter Study on the Impact of Staged Valvular Interventions on Outcomes.
Al-Kassou B, Kapplinghaus J, Meckelburg C, Shamekhi J, Aksoy A, Wienemann H, Al-Kassou L, Zietzer A, Sugiura A, Tiyerili V, Eckel C, Vogelhuber J, Weber M, Zeus T, Adam M, Möllmann H, Abdel-Wahab M, Thiele H, Baldus S, Kelm M, Bakhtiary F, Nickenig G, Zimmer S.
J Am Heart Assoc. 2025 Jun 17;14(12):e040150. doi: 10.1161/JAHA.124.040150.
The role of uremic toxin indoxyl sulfate in the pathophysiology of aortic valve stenosis.
Düsing P, Göbel I, Ackerschott A, Reese L, Giavalisco P, Dethloff F, Niepmann ST, Stei M, Beiert T, Zimmer S, Kurts C, Nickenig G, Jansen F, Zietzer A.
Cardiovasc Res. 2025 Jun 17:cvaf106. doi: 10.1093/cvr/cvaf106.
Predictive performance of the TRI-SCORE in patients with severe aortic stenosis and concomitant tricuspid regurgitation undergoing TAVR.
Mousa Basha M, Al-Kassou B, Gestrich C, Weber M, Beiert T, Zimmer S, Bakhtiary F, Nickenig G, Shamekhi J.
Clin Res Cardiol. 2025 May 12. doi: 10.1007/s00392-025-02671-y.
Mutational landscape and impact of clonal hematopoiesis of indeterminate potential in severe aortic valve stenosis.
Jamin RN, Al-Kassou B, Kleuker T, Shamekhi J, Bartsch B, Ackerschott A, Al Zaidi M, Billig H, Graef CM, Kelm M, Baldus S, Nickenig G, Latz E, Zimmer S.
Clin Res Cardiol. 2025 May 5. doi: 10.1007/s00392-025-02658-9.
CCR2 dependent recruited pro-inflammatory monocytes contribute to the development of left ventricular hypertrophy in mice upon transverse aortic constriction.
Eichhorn L, Kleiner JL, Bartsch B, Nazir MLF, Zhang Y, Coburn M, Frede S, Weisheit CK.
PLoS One. 2025 Apr 21;20(4):e0318407. doi: 10.1371/journal.pone.0318407.
MLKL activity requires a splicing-regulated, druggable intramolecular interaction.
Ros U, Martinez-Osorio V, Valiente PA, Abdelwahab Y, Gojkovic M, Shalaby R, Zanna S, Saggau J, Wachsmuth L, Nemade HN, Zoeller J, Lottermoser H, Chen YG, Ibrahim M, Kelepouras K, Vasilikos L, Bedoya P, Espiritu RA, Müller S, Altmannova V, Tieleman DP, Weir J, Langer J, Adam M, Walczak H, Wong WW, Liccardi G, Mollenhauer M, Pasparakis M, Peltzer N, García-Sáez AJ.
Mol Cell. 2025 Apr 17;85(8):1589-1605.e12. doi: 10.1016/j.molcel.2025.03.015.
A novel approach to studying infective endocarditis: Ultrasound-guided wire injury and bacterial challenge in mice.
Bartsch B, Ackerschott A, Al Zaidi M, Jamin RN, Nazir MLF, Altrogge M, Fester L, Lambertz J, Coburn M, Nickenig G, Parcina M, Zimmer S, Weisheit CK.
PLoS One. 2025 Apr 7;20(4):e0318955. doi: 10.1371/journal.pone.0318955.
Protocol for the site-specific isolation of mouse endothelial cells using the modified Häutchen technique.
Brückner A, Brandtner A, Rieck S, Fleischmann BK, Wenzel D.
STAR Protoc. 2025 Mar 21;6(1):103620. doi: 10.1016/j.xpro.2025.103620.
Sex-related hormonal variances and clinical outcomes in TAVR patients.
Mousa Basha M, Al-Kassou B, Weber M, Beiert T, Bakhtiary F, Zimmer S, Nickenig G, Goody PR, Shamekhi J.
Clin Res Cardiol. 2025 Feb 24. doi: 10.1007/s00392-025-02623-6.
Prodomain processing controls BMP-10 bioactivity and targeting to fibrillin-1 in latent conformation.
Spanou CES, Yang C, Godwin ARF, Morosky S, Anbalagan A, Lütke S, Mörgelin M, Marcous F, Aziz U, Wohl AP, Jabeen I, Koch M, Jowitt TA, Roman BL, Tarakanova A, Baldock C, Sengle G.
FASEB J. 2025 Feb 15;39(3):e70373. doi: 10.1096/fj.202401694R.
Distinct Genetic Risk Profile in Aortic Stenosis Compared With Coronary Artery Disease.
Trenkwalder T, Maj C, Al-Kassou B, Debiec R, Doppler SA, Musameh MD, Nelson CP, Dasmeh P, Grover S, Knoll K, Naamanka J, Mordi IR, Braund PS, Dreßen M, Lahm H, Wirth F, Baldus S, Kelm M, von Scheidt M, Krefting J, Ellinghaus D, Small AM, Peloso GM, Natarajan P, Thanassoulis G, Engert JC, Dufresne L, Franke A, Görg S, Laudes M, Nowak-Göttl U, Vaht M, Metspalu A, Stoll M, Berger K, Pellegrini C, Kastrati A, Hengstenberg C, Lang CC, Kessler T, Hovatta I, Nickenig G, Nöthen MM, Krane M, Schunkert H, Samani NJ, Schumacher J, Kals M, Reigo A, Teder-Laving M, Gehlen J, Webb TR, Giel AS, Koebbe LL, Feirer N, Billmann M, Srinivasan S, Zimmer S, Palmer CNA, Li L, Yang C, Borisov O, Adam M, Veulemans V, Joner M, Xhepa E; TARGET Consortium; Estonian Biobank; and the European Consortium for Genetics of Aortic Stenosis (EGAS).
JAMA Cardiol. 2025 Feb 1;10(2):145-154. doi: 10.1001/jamacardio.2024.3738.