Publications of the TRR259 - 2024
The bile acid receptor TGR5 inhibits platelet activation and thrombus formation.
Reusswig F, Reich M, Wienands L, Herebian D, Keitel-Anselmino V, Elvers M.
Platelets. 2024 Dec;35(1):2322733. doi: 10.1080/09537104.2024.2322733.
Site-specific genetic and functional signatures of aortic endothelial cells at aneurysm predilection sites in healthy and AngII ApoE-/- mice.
Brückner A, Brandtner A, Rieck S, Matthey M, Geisen C, Fels B, Stei M, Kusche-Vihrog K, Fleischmann BK, Wenzel D.
Angiogenesis. 2024 Nov;27(4):719-738. doi: 10.1007/s10456-024-09933-9.
Impact of Measured and Predicted Prosthesis-Patient Mismatch After Transcatheter Aortic Valve Replacement.
Guthoff H, Abdel-Wahab M, Kim WK, Witberg G, Wienemann H, Thurow M, Shamekhi J, Eckel C, von der Heide I, Veulemans V, Landt M, Barbanti M, Finkelstein A, Schewel J, Van Mieghem N, Adrichem R, Toggweiler S, Rheude T, Nombela-Franco L, Amat-Santos IJ, Ruile P, Estévez-Loureiro R, Bunc M, Branca L, De Backer O, Tarantini G, Mylotte D, Arzamendi D, Pauly M, Bleiziffer S, Renker M, Al-Kassou B, Möllmann H, Ludwig S, Zeus T, Tamburino C, Schmidt T, Rück A, von Stein P, Thiele H, Abdelhafez A, Adam M, Baldus S, Rudolph T, Mauri V; IMPPACT TAVR Investigators.
JACC Cardiovasc Interv. 2024 Nov 25;17(22):2626-2635. doi: 10.1016/j.jcin.2024.08.041.
Hematopoietic PI3Kδ deficiency aggravates murine atherosclerosis through impairment of Tregs.
Zierden M, Berghausen EM, Gnatzy-Feik L, Millarg C, Picard FSR, Kiljan M, Geißen S, Polykratis A, Zimmermann L, Nies RJ, Pasparakis M, Baldus S, Valasarajan C, Pullamsetti SS, Winkels H, Vantler M, Rosenkranz S.
JCI Insight. 2024 Nov 22;9(22):e155626. doi: 10.1172/jci.insight.155626.
Decoding Macrophage Heterogeneity to Unravel Vascular Inflammation as a Path to Precision Medicine.
Chelvanambi S, Decano JL, Winkels H, Giannarelli C, Aikawa M.
Arterioscler Thromb Vasc Biol. 2024 Nov;44(11):2253-2257. doi: 10.1161/ATVBAHA.124.319571.
GP VI–Mediated Platelet Activation and Procoagulant Activity Aggravate Inflammation and Aortic Wall Remodeling in Abdominal Aortic Aneurysm.
Feige T, Bosbach A, Krott KJ, Mulorz J, Chatterjee M, Ortscheid J, Krüger E, Krüger I, Salehzadeh N, Goebel S, Ibing W, Grandoch M, Münch G, Wagenhäuser MU, Schelzig H, Elvers M.
Arterioscler Thromb Vasc Biol. 2024 Nov;44(11):2294-2317. doi: 10.1161/ATVBAHA.123.320615.
Forward programming of human induced pluripotent stem cells via the ETS variant transcription factor 2: rapid, reproducible, and cost-effective generation of highly enriched, functional endothelial cells.
Rieck S, Sharma K, Altringer C, Hesse M, Triantafyllou C, Zhang Y, Busskamp V, Fleischmann BK.
Cardiovasc Res. 2024 Oct 14;120(12):1472-1484. doi: 10.1093/cvr/cvae129.
Aortic Valve Stenosis Causes Accumulation of Extracellular Hemoglobin and Systemic Endothelial Dysfunction.
Quast C, Bönner F, Polzin A, Veulemans V, Chennupati R, Gyamfi Poku I, Pfeiler S, Kramser N, Nankinova M, Staub N, Zweck E, Jokiel J, Keyser F, Hoffe J, Witkowski S, Becker K, Leuders P, Zako S, Erkens R, Jung C, Flögel U, Wang T, Neidlin M, Steinseifer U, Niepmann ST, Zimmer S, Gerdes N, Cortese-Krott MM, Feelisch M, Zeus T, Kelm M.
Circulation. 2024 Sep 17;150(12):952-965. doi: 10.1161/CIRCULATIONAHA.123.064747.
Microbial growth on temporary pacemaker leads post-TAVR: pathogen spectrum and clinical implications.
Mousa Basha M, Al-Kassou B, Gestrich C, Weber M, Beiert T, Bakhtiary F, Nickenig G, Zimmer S, Shamekhi J.
Clin Res Cardiol. 2024 Sep 10. doi: 10.1007/s00392-024-02543-x.
Platelet transcription factors license the pro-inflammatory cytokine response of human monocytes.
Hawwari I, Rossnagel L, Rosero N, Maasewerd S, Vasconcelos MB, Jentzsch M, Demczuk A, Teichmann LL, Meffert L, Bertheloot D, Ribeiro LS, Kallabis S, Meissner F, Arditi M, Atici AE, Noval Rivas M, Franklin BS.
EMBO Mol Med. 2024 Aug;16(8):1901-1929. doi: 10.1038/s44321-024-00093-3.
Loss of ceramide synthase 5 inhibits the development of experimentally induced aortic valve stenosis.
Reese L, Niepmann ST, Düsing P, Hänschke L, Beiert T, Zimmer S, Nickenig G, Bauer R, Jansen F, Zietzer A.
Acta Physiol (Oxf). 2024 May;240(5):e14140. doi: 10.1111/apha.14140.
Crosstalk of platelets with macrophages and fibroblasts aggravates inflammation, aortic wall stiffening, and osteopontin release in abdominal aortic aneurysm.
Wagenhäuser MU, Mulorz J, Krott KJ, Bosbach A, Feige T, Rhee YH, Chatterjee M, Petzold N, Böddeker C, Ibing W, Krüger I, Popovic AM, Roseman A, Spin JM, Tsao PS, Schelzig H, Elvers M.
Cardiovasc Res. 2024 Mar 30;120(4):417-432. doi: 10.1093/cvr/cvad168.
Trained Innate Immunity in Animal Models of Cardiovascular Diseases.
Kleimann P, Irschfeld LM, Grandoch M, Flögel U, Temme S.
Int J Mol Sci. 2024 Feb 15;25(4):2312. doi: 10.3390/ijms25042312.
Relative Thrombus Burden Ratio Reveals Overproportioned Intraluminal Thrombus Growth—Potential Implications for Abdominal Aortic Aneurysm.
Mulorz J, Mazrekaj A, Sehl J, Arnautovic A, Garabet W, Krott KJ, Schelzig H, Elvers M, Wagenhäuser MU.
J Clin Med. 2024 Feb 8;13(4):962. doi: 10.3390/jcm13040962.
Cholesterol Crystal Dissolution Rate of Serum Predicts Outcomes in Patients With Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement.
Al-Kassou B, Al-Kassou L, Mahn T, Lütjohann D, Shamekhi J, Willemsen N, Niepmann ST, Baldus S, Kelm M, Nickenig G, Latz E, Zimmer S.
J Am Heart Assoc. 2024 Feb 6;13(3):e031997. doi: 10.1161/JAHA.123.031997.
Macrophage Mediators and Mechanisms in Cardiovascular Disease.
Schelemei P, Wagner E, Picard FS, Winkels H.
FASEB J. 2024 Feb;38(2):e23424. doi: 10.1096/fj.202302001R.
EPAC1 enhances brown fat growth and beige adipogenesis.
Reverte-Salisa L, Siddig S, Hildebrand S, Yao X, Zurkovic J, Jaeckstein MY, Heeren J, Lezoualc'h F, Krahmer N, Pfeifer A.
Nat Cell Biol. 2024 Jan;26(1):113-123. doi: 10.1038/s41556-023-01311-9.
A simply calculated nutritional index provides clinical implications in patients undergoing transcatheter aortic valve replacement.
Sudo M, Shamekhi J, Aksoy A, Al-Kassou B, Tanaka T, Silaschi M, Weber M, Nickenig G, Zimmer S.
Clin Res Cardiol. 2024 Jan;113(1):58-67. doi: 10.1007/s00392-023-02220-5.