S01-Animal models
The entire consortium of TRR259 is dependent on complex animal models that adequately resemble the molecular pathologies of aortic valve stenosis (AS) and aortic aneurysm (AA) formation. Project S01 serves as a central unit for a) providing animal models, b) comprehensive imaging and phenotyping, c) training of surgical and imaging skills, and d) quality management and assurance across the research sites in Bonn, Cologne and Düsseldorf. Project S01 developed and deeply phenotyped several animal models of experimental aortic valve stenosis and aortic aneurysm formation and has generated extensive baseline data sets for quality control during the first funding period. Furthermore, it has provided the scientific and personnel infrastructure to develop and establish a large animal model of aortic aneurysm formation in pigs. In the upcoming second funding period, S01 will not only continue its efforts to offer highly reliable experimental animal models but also coordinate the development and characterisation of novel techniques and large-animal models of aortic disease.
Contacts
Prof. Dr. Sebastian Zimmer
Heart Center, Building 26
Department Medical Clinic and Polyclinic II
University Hospital Bonn
Venusberg-Campus 1
53127 Bonn
Prof. Dr. Gerhard Sengle
Center for Biochemistry II
Center for Molecular Medicine Cologne (CMMC)
Joseph-Stelzmann-Strasse 52
50931 Cologne
Dr. Christine Quast
Division of Cardiology, Pulmonology and Vascular Medicine
University Hospital Düsseldorf
Moorenstraße 5
40225 Düsseldorf
Prof. Dr. Norbert Gerdes
Building 13.58, U1, Room 003
Division of Cardiology, Pulmonology and Vascular Medicine
Mailbox 1125
University Hospital Düsseldorf
Moorenstr. 5
40225 Düsseldorf
Dr. nat. med. Annika Roth
Building 13.58, U1, Room 004
Clinic for Cardiology, Pneumology and Angiology
University Hospital Düsseldorf
Moorenstr. 5
40225 Düsseldorf
Dr. Sven Thomas Niepmann
Heart Center, Building 26
Clinic for Internal Medicine II
University Hospital Bonn
Venusberg-Campus 1
53127 Bonn
Dr. Marko Bulic
Heart Center, Building 26
Clinic for Internal Medicine II
University Hospital Bonn
Venusberg-Campus 1
53127 Bonn
Dr. Moritz Nöthel
Heart Center, Building 26
Clinic for Internal Medicine II
University Hospital Bonn
Venusberg-Campus 1
53127 Bonn
Dr. Hannah Billig
Heart Center, Building 26
Clinic for Internal Medicine II
University Hospital Bonn
Venusberg-Campus 1
53127 Bonn
Dr. Ansgar Ackerschott
Biomedical Center I, Building 13, Floor 3
Clinic for Internal Medicine II
University Hospital Bonn
Venusberg-Campus 1
53127 Bonn
Dr. Sandra Adler
Biomedical Center I, Building 13, Floor 3, Room 010
Clinic for Internal Medicine II
Department of Molecular Cardiology
University Hospital Bonn
Venusberg-Campus 1
53127 Bonn
Dr. med. vet. Marta Stei
Biomedical Center I, Building 13, Floor 3, Room 10
Clinic for Internal Medicine II
Department of Molecular Cardiology
University Hospital Bonn
Venusberg-Campus 1
53127 Bonn
Dr. Dagmar Sonntag-Bensch
Center for Biochemistry II
Center for Molecular Medicine Cologne (CMMC)
Joseph-Stelzmann-Strasse 52
50931 Cologne
Gloria Martinac
Biomedical Center I, Building 13, Floor 3, Room 10
Clinic for Internal Medicine II
Department of Molecular Cardiology
University Hospital Bonn
Venusberg-Campus 1
53127 Bonn
Pia Fuchs
Biomedical Center I, Building 13, Floor 3, Room 10
Clinic for Internal Medicine II
Department of Molecular Cardiology
University Hospital Bonn
Venusberg-Campus 1
53127 Bonn
Julia Odendahl
Division of Cardiology, Pulmonology and Vascular Medicine
University Hospital Düsseldorf
Moorenstraße 5
40225 Düsseldorf
Henning Panatzek