A09-The role of the olfactory receptor 2 in aortic aneurysm formation

Macrophages contribute to inflammatory processes and extracellular matrix remodelling in abdominal aortic aneurysm (AAA) formation. Therefore, the modulation of inflammatory and matrix-degrading macrophage phenotypes represents an attractive strategy to reduce vascular inflammation and AAA. Recently, extra-nasal olfactory receptor 2 (Olfr2) expression in vascular macrophages has been shown to modulate their inflammatory response. We will determine how Olfr2 contributes to AAA formation and the accompanying vascular macrophage response in Olfr2-deficient mice. Finally, by genetically and pharmacologically inhibiting or augmenting Olfr2 signalling, we will test if Olfr2 is a novel therapeutic target in AAA.