C04-Characterising the innate immune response to decellularised extracellular matrix-based heart valve and aortic implants

Decellularised human heart valves (DHV) are a promising therapeutic approach for heart valve replacement in terms of biocompatibility and durability. Nonetheless, early and late degeneration of aortic DHVs has been observed in some patients, with several studies implicating the immune response to the decellularised extracellular matrix (dECM) in this process. In this project, we aim to characterise the immune response to dECM graft material and investigate how its modulation may affect host integration of dECM-based implants. Altogether, we hope to establish the molecular groundwork for targeted pharmacological therapies to improve integration, biocompatibility, and durability of DHVs.

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© Sebastian Zimmer

Contacts

Avatar Aubin

PD Dr. Hug Aubin

MHBA

Project leader C04

Clinic for Cardiac Surgery - Cardiovascular Regenerative Medicine & Tissue Engineering 3D Lab

University Hospital Düsseldorf

Moorenstraße 5

40225 Düsseldorf

Avatar Bartok

Prof. Eva Bartok

MD

Project leader C04

Building 12, 1st Floor, Room 1G409

Institute for Experimental Hematology and Transfusion Medicine (IHT)

University Hospital Bonn

Venusberg-Campus 1

53127 Bonn

Avatar Lichtenberg

Prof. Dr. Artur Lichtenberg

Co-project leader C04

Clinic for Cardiac Surgery

University Hospital Düsseldorf

Moorenstraße 5

40225 Düsseldorf

Avatar Weber

Dr. Elvira Weber

Postdoc

Clinic for Cardiac Surgery

Cardiovascular Regenerative Medicine & Tissue Engineering 3D Lab

University Hospital Düsseldorf

Moorenstraße 5

40225 Düsseldorf

Avatar Chekhoeva

Dr. Agunda Chekhoeva

Postdoc

Clinic for Cardiac Surgery

University Hospital Düsseldorf

Moorenstraße 5

40225 Düsseldorf

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