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B01-Endothelial disease mechanisms involved in calcific aortic valve stenosis and aortic aneurysm formation in mice and men

Aortic valve stenosis (AS) and aortic aneurysm (AA) develop at specific predilection sites. Our recent evidence indicates that there is extensive molecular heterogeneity of the endothelium. Therefore, we postulate that this defines the location, onset and progression of AS and AA. In this project, we will determine and characterise molecular endothelial markers for the site-specific disease development in mice and humans. We will correlate these findings with drug-induced transcriptomic signatures (repurposing strategy) to develop a potential pharmacological treatment approach.

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© Sebastian Zimmer

Contacts

Avatar Wenzel

Prof. Dr. Daniela Wenzel

Project leader B01

MA 2/147

Universitätsstr. 150

44801 Bochum

Abteilung für Systemphysiologie

+49 234-32 29101

Avatar Fleischmann

Prof. Dr. Bernd Fleischmann

Project leader B01

Life & Brain Center, 1st floor

Venusberg-Campus 1

53127 Bonn

Institute of Physiology I

+49 228 73 60200

Avatar Brückner

Alexander Brückner

PhD-Student

Life & Brain Center, 1st floor

Venusberg-Campus 1

53127 Bonn

Institute of Physiology I

+49 228 6885-

Avatar Brandtner

Adrian Brandtner

PhD-Student

Life & Brain Center, 1st floor

Venusberg-Campus 1

53127 Bonn

Institute of Physiology I

+49 228 6885-

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