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A08-Influence of perivascular brown adipose tissue on aortic valve disease

Perivascular adipose tissue (PVAT) is a type of thermogenic adipose tissue that lines large blood vessels, including the aorta. Given the beneficial effects of thermogenic adipose tissue activity in cardiovascular disease, we hypothesised that activation of PVAT mediates important protective effects in aortic disease during physiological activation by cold exposure. In the previous funding period, we identified an important role for PVAT in regulating aortic function and stenosis. In the second funding period, we will analyse the precise mechanisms through which PVAT influences aortic function and disease as well as functionally characterise molecular targets that were identified during the first funding period. Moreover, we will also focus on the secretomic and metabolomic crosstalk between PVAT and the aortic wall in the context of aneurysm formation.

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© Sebastian Zimmer

Contacts

Avatar Pfeifer

Prof. Dr. Alexander Pfeifer

Project leader A08

Biomedical Center I, Building 13, 2OG, room 14

Venusberg-Campus 1

53127 Bonn

Institute for Pharmacology and Toxicology

+49 228 287-51300

Avatar Hildebrand

Dr. Staffan Hildebrand

Project leader A08

Biomedical Center I, Building 13, 1OG

Venusberg-Campus 1

53127 Bonn

Institute for Pharmacology and Toxicology

+49 228 287-51261

Avatar Schmidt

Alexander Schmidt

PhD student

Venusberg-Campus 1

53127 Bonn

Institute for Pharmacology and Toxicology

+ 49 (0) 228 287

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