A02-Danger signaling pathways in aortic disease
Chronic inflammation is responsible for the development and progression of aortic disease. In the first funding period, we demonstrated that specific activation of the innate immune system is critical for this pro-inflammatory state. Project A02 will expand on these findings by deciphering what cell types mediate the observed effects using conditional mice and specific in vitro models. For translation, we will test therapeutic interventions targeting innate immune receptor activation. Finally, we will study the role of danger signalling mechanisms of monocytes with specific pro-inflammatory genetic predispositions, termed clonal haematopoiesis of indeterminate potential (CHIP), in the development of aortic disease.

Contacts
Prof. Dr. Sebastian Zimmer
Heart Center, Building 26
Venusberg-Campus 1
53127 Bonn
Heart Center, Building 26
Prof. Dr. Eicke Latz
Biomedical Center II, Building 12, 1OG
Venusberg-Campus 1
53127 Bonn
Institute of Innate Immunity
Dr. Sven Thomas Niepmann
Department of Molecular Cardiology
Venusberg-Campus 1
53127 Bonn
Clinic for Internal Medicine II
Nicola Willemsen
Biomedical Center I, Building 13, 3OG, room 14
Venusberg-Campus 1
53127 Bonn
Department of Molecular Cardiology