Title of the Study
„Calcific aortic valve disease augments vesicular microRNA-145-5p to regulate the calcification of valvular interstitial cells via cellular crosstalk.”
Published on August 22, 2025
https://link.springer.com/article/10.1007/s00395-025-01133-w
Authors
Goody PR, Christmann D, Goody D, Hildebrand S, Billig H, Nehl D, Chennupati R, Gladka M, Wilhelm-Jüngling K, Uchida S, Iris-Bibli S, Moore JB 4th, Hamdani N, Paneni F, Pullamsetti SS, Zimmer S, Jansen F, Bakhtiary F, Aikawa E, Pfeifer A, Nickenig G, Hosen MR
Key Findings
This study is particularly important to uncover the mechanisms of a complex and deadly disease of Aortic Stenosis, where no medical treatment option is available to slow, halt, or reverse the progression of the disease.
🦠 We provided a comprehensive scheme of mechanisms with a potential tool for RNA-based therapeutics.
📣Our highlights:
✅During CAVD, the expression pattern of tissue-derived and vesicle-enriched (circulating) regulatory miRNAs changes.
✅Patient-derived aortic valve tissue, as well as aortic valve explants from an experimental murine aortic valve stenosis model, demonstrated an increased expression of miR-145-5p in humans and mice.
✅MiR145-5p contributes to calcification of the aortic valve through ZEB2, a transcriptional repressor of ALPL, in valvular interstitial cells.
hashtag#Extracellular vesicle shuttling of miR-145-5p contributes to valvular cell-cell crosstalk and plays a role in the pathogenesis of CAVD.
✅Big thanks to collaborators, colleagues, and funding authorities: DFG (German Research Foundation, DGK (German Society of Cardiology), Corona Foundation, German Heart Foundation (DSHF).