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A07

Role of platelets on aortic aneurysm

The project aims to explore how platelets may contribute to the development and progression of aortic aneurysm (AA). Platelets are small cell fragments that are derived from bone marrow. Once they are activated, platelets are capable to release various pro-inflammatory cytokines and other biological response modulators, suggesting a pivotal role in AA by both direct and indirect interaction with resident and non-resident cell types. That being said, the project focuses to understand how platelets get activated in the aortic wall and to identify relevant downstream signaling pathways which promote the progression of the disease. At long-term, it seems of utmost interest to understand the role of platelets and their disease-specific activation and interactions to detect promising therapeutic targets and to ultimately block AA initiation or attenuate diameter progression.

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