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Receptor makes mice strong and slim

Study by the University of Bonn identifies molecule that regulates two side effects of aging

June 25, 2020

Increasing abdominal girth and shrinking muscles are two common side effects of aging. Researchers at the University of Bonn have discovered a receptor in mice that regulates both effects. Experiments with human cell cultures suggest that the corresponding signaling pathways might also exist in humans. The study, which also involved researchers from Spain, Finland, Belgium, Denmark and the USA, has now been published in the renowned journal "Cell Metabolism"


Find here the english press release.



Thorsten Gnad, Gemma Navarro, Minna Lahesmaa, Laia Reverte-Salisa, Francesca Copperi, Arnau Cordomi, Jennifer Naumann, Aileen Hochhäuser, Saskia Haufs-Brusberg, Daniela Wenzel, Frank Suhr, Naja Zenius Jespersen, Camilla Scheele, Volodymyr Tsvilovskyy, Christian Brinkmann, Joern Rittweger, Christian Dani, Mathias Kranz, Winnie Deuther-Conrad, Holger K. Eltzschig, Tarja Niemi, Markku Taittonen, Peter Brust, Pirjo Nuutila, Leonardo Pardo, Bernd K. Fleischmann, Matthias Blüher, Rafael Franco, Wilhelm Bloch, Kirsi A. Virtanen, Alexander Pfeifer

the A2B receptors_A.Pfeifer

Examined the A2B receptors in brown adipose tissue:
Prof. Dr. Alexander Pfeifer (left) and Dr. Thorsten Gnad (right) from the Institute of Pharmacology and Toxicology at the University Hospital Bonn. (c) Katharina Wislsperger/UKBonn


Adenosine/A2B receptor signaling ameliorates the effects of ageing and counteracts obesity. Cell Metabolism, DOI:



Alexander Pfeifer
Institute of Pharmacology and Toxicology
University Hospital
University of Bonn
53127 Bonn, Germany


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